Publikationen

Axer H*, Romeike BFM, Brunkhorst FM, Zinke J, Ringer TM, Günther A: Neurological sequelae of sepsis: II) Neuromuscular weakness. The Open Critical Care Medicine Journal 2011, 4:8-14.

Bauer M, Witte OW, Heinemann SH:  Carbon monoxide and outcome of stroke--a dream CORM true? Crit Care Med 2012 Feb, 40(2):687-8. IF 6.254

Brunkhorst FM, Oppert M, Marx G, Bloos F, Ludewig K, Putensen C, Nierhaus A, Jaschinski U, Meier-Hellmann A, Weyland A, Gründling M, Moerer O, Riessen R, Seibel A, Ragaller M, Büchler MW, John S, Bach F, Spies C, Reill L, Fritz H, Kiehntopf M, Kuhnt E, Bogatsch H, Engel C, Loeffler M, Kollef MH, Reinhart K, Welte T (for the German Study Group Competence Network Sepsis, SepNet): Effect of Empirical Treatment With Moxifloxacin and Meropenem vs Meropenemon Sepsis-Related Organ Dysfunction in Patients With Severe Sepsis A Randomized Trial. JAMA 2012, 307(22):2390-2399. IF 30.011

Bruns T, Peter J, Hagel S, Herrmann A , Stallmach  A: The augmented neutrophil respiratory burst in response to Escherichia coli is reduced in liver cirrhosis during infection. Clin Exp Immunol 2011, 164(3): 346-356. IF 3.134

Bruns T, Peter J, Hagel S, Pfeifer R, Prinz P, Stallmach A: Homozygous carrier of the NOD2 1007fs frame-shift mutation presenting with refractory community-acquired spontaneous bacterial peritonitis and developing fatal pulmonary mucormycosis: A case report. Hepatol Res 2011, 41:1009-1014. IF 1.857

Bruns T, Reuken PA, Fischer J, Berg T, Stallmach A: Further evidence for the relevance of TLR2 gene variants in spontaneous bacterial peritonitis. J Hepatol 2011, 55:1010-6. IF 9.334

Bruns T, Peter J, Reuken PA, Grabe DH, Schuldes SR, Brenmoehl J, Schölmerich J, Wiest R, Stallmach A: NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis. Liver Int 2012, 32:223-230. IF 3.840

Bruns T, Wiest R, Stallmach A: NOD2 gene variants and spontaneous bacterial peritonitis: authors’ reply. Liver Int 2012, 32:521-522. IF 3.840

Bruns T, Stallmach A. [Spontaneous and Secondary Bacterial Peritonitis in Cirrhotic Patients with Ascites.]. Zentralbl Chir 2011. in press. Doi: 10.1055/s-0031-1283815 IF 1.023

Citiulo F, Jacobsen ID, Miramon P, Schild L, Brunke S, Zipfel P, Brock M, Hube B, Wilson D: Candida albicans Scavenges Host Zinc via Pra1 during Endothelial Invasion. PLoS Pathogens 2012, in press IF 9.079

Godfrey R, Arora D, Bauer R, Stopp S, Muller JP, Heinrich T, Bohmer SA, Dagnell M, Schnetzke U, Scholl S, Ostman A, Bohmer FD: Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ. Blood 2012, 119:4499-4511. IF 10.558

Gonnert FA, Recknagel P, Seidel M, Jbeily N, Dahlke K, Bockmeyer CL, Winning J, Lösche W, Claus RA, Bauer M: Characteristics of clinical sepsis reflected in a reliable and reproducible rodent sepsis model. J Surg Res 2011 Sep, 170(1):e123-34. IF 2.239

Gonnert FA, Kunisch E, Gajda M, Lambeck S, Weber M, Claus RA, Bauer M, Kinne RW: Hepatic Fibrosis in a Long-Term Murine Model of Sepsis. Shock 2012 Apr, 37(4):399-407. IF 3.203

Gow NA, Hube B: Importance of the Candida albicans cell wall during commensalism and infection. Curr Opin Microbiol 2012, May 17. IF 7.714

Hagel S, Brunkhorst FM: Sepsis. Intensivmed 2012, 48:57-73.

Hagel S: ALERTS - Krankenhausinfektionen vermeiden, Hyg Med 2011, 36-39.

Hagel S, Bruns T, Herrmann A, Stallmach A, Schmidt C: Abnormal Glucose Tolerance: A Predictor Of 30-Day Mortality In Patients With Decompensated Liver Cirrhosis. Z Gastroenterol. 2011 Mar, 49(3):331-334. IF 1.131

Hartog CS, Skupin H, et al (2011) Systematic analysis of hydroxyethyl starch (HES) reviews: proliferation of low quality reviews overwhelms the results of well-performed meta-analyses. Intensive Care Med, in press

Jacobsen ID, Wilson D, Wächtler B, Brunke S, Naglik JR, Hube B: Candida albicans dimorphism as a therapeutic target. Expert Rev Anti Infect Ther 2012, 10(1):85-93. IF 3.090

Jaenichen D, Brunkhorst FM, Strauß B, Rosendahl J: Körperliche und psychische Langzeitfolgen nach intensiv-medizinischer Behandlung einer schweren Sepsis bei Patienten und Angehörigen. Psychother Psych Med 2012, 62: 1-11. IF 1.214

Kiehntopf M, Schmerler D, Brunkhorst FM, Winkler R, Ludewig K, Osterloh D, Bloos F, Reinhart K, Deufel T: Mass spectometry-based protein patterns in the diagnosis of sepsis/systemic inflammatory response syndrome. Shock 2011 Dec, 36(6):560-9. IF 3.203

Kleiman A, Huebner S, Rodriguez Parkitna JM, Neumann A, Hofer S, Weigand MA, Bauer M, Schmid W, Schuetz G, Libert C, Reichardt HM, Tuckermann JP: Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages. FASEB J. 2012 Feb;26(2):722-9. IF 6.515

Kotsaki A, Giamarellos-Bourboulis EJ: Emerging drugs for the treatment of sepsis. Expert Opin Emerging Drugs 2012, 17:3, 1-13. IF 3.824

Kotzampassi K, Giamarellos-Bourboulis EJ: Probiotics for Infectious diseases: More drugs less dietary supplementation, Int J Antimicrobial Agents 2012, E-pub Aug2. IF 3.787

Lambeck S, Weber M, Gonnert FA, Mrowka R, Bauer M. Comparison of sepsis‐induced transcriptomic changes in a murine model to clinical blood samples identifies common response patterns. Frontiers: Systems Biology of Microbial Infection. [Epub ahead of print].

Lösche W, Boettel J, Kabisch B, Winning J, Claus RA, Bauer M: Do aspirin and other antiplatelet drugs reduce the mortality in critically ill patients? Thrombosis 2012, 720254.

Mariappan A, Makarewicz O, Chen XH, Borriss R: Two-Component Response Regulator DegU Controls the Expression of Bacilysin in Plant-Growth-Promoting Bacterium Bacillus amyloliquefaciens FZB42. J Mol Microbiol Biotechnol. 2012 Jun 7, 22(2):114-125. IF 4.588

Mayer FL, Wilson D, Jacobsen ID, Miramón P, Slesiona S, Bohovych IM, Brown AJ, Hube B: Small but Crucial: The Novel Small Heat Shock Protein Hsp21 Mediates Stress Adaptation and Virulence in Candida albicans. PLoS One 2012, 7(6):e38584. IF 4.411

Neugebauer U, März A, Henkel M., Popp J: Spectroscopic detection and quantification of heme and heme degradation products. Anal Bioanal Chem 2012, in press. DOI: 10.1007/s00216-012-6288-9. IF 3.841

Otto GP, Wissuwa B, Mehnert A, Marx S, Raessler M, Lösche W, Claus RA, Sossdorf M: A method for detection and quantification of hydroxyethyl starch in plasma, Critical Care 2012, 16:426  (letter) IF 4.595

Otto GP, Neugebauer S, Claus RA, Sossdorf M: Arginine metabolism is markedly impaired in polymicrobial infected mice. Crit Care 2012, 16:412. IF 4.93

Quintin J, Saeed S, Martens JHA, Giamarellos-Bourboulis EJ, Ifrim DC, Logie C, Jacobs L, Jansen T, Kullberg BJ, Wijmenga C, Joosten LAB, Xavier RJ, van der Meer JWM, Stunnenberg HG, Netea MG. Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes. Cell Host and Microbe 2012; 12: 223-232 IF 13.500

Ramoji A, Neugebauer U, Bocklitz T, Foerster M, Kiehntopf M, Bauer M, Popp J: Toward a Spectroscopic Hemogram: Raman Spectroscopic Differentiation of the Two Most Abundant Leukocytes from Peripheral Blood. Analytical Chemistry, Anal Chem 2012, 84 (12), pp 5335-5342. IF 5.874

Rauchfuss F, Lambeck S, Claus RA, Ullmann J, Schulz T, Weber M, Katenkamp K, Guthke R, Bauer M, Settmacher U: Sustained liver regeneration after portal vein embolization - A human molecular pilot study. Dig Liver Dis 2012 May 4. IF 2.805

Recknagel P, Claus RA, Neugebauer U, Bauer M,  Gonnert FA: In vivo imaging of hepatic excretory function in the rat by fluorescence microscopy. J Biophotonics. 2012 Jan 23, [Epub ahead of print]. IF 4.240

Recknagel P, Gonnert FA, Westermann M., Lambeck S, Lupp A, Rudiger A, Dyson A, Carré JE, Kortgen A, Krafft C, Popp J, Sponholz C, Fuhrmann V, Hilger I, Claus RA, Riedemann NC, Wetzker R, Singer M, Trauner M, Bauer M:  Liver Dysfunction and Phosphatidylinositol-3-kinase Signaling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis. PLoS Medicine, 2012 accepted. IF 16.8

Reinhart K, Bauer M, Riedemann NC, Hartog C: New Approaches to Sepsis: Molecular Diagnosis and Biomarkers. Clinical Microbiology Review 2012, 4(October) in press. IF 16.129

Reuken PA, Bruns T, Zimmer B, Michael A, Brunkhorst FM, Pletz MW, Stallmach, A: Recurrent fever and bacteraemia after endoscopic variceal haemostasis with cyanoacrylate: a case report." Infection 2012 Jun, 40(3):351-3. IF 2.244

Reuken PA, Pletz MW, Baier M, Pfister W, Stallmach A, Bruns T: Emergence of spontaneous bacterial peritonitis due to enterococci - risk factors and outcome in a 12-year retrospective study, Aliment Pharmacol Ther 2012, 35: 1199-1208. IF 3.861

Reuken PA, Kiehntopf M, Stallmach A, Bruns T: Mid-regional pro-adrenomedullin (MR-proADM): An even better prognostic biomarker than C-reactive protein to predict short-term survival in patients with decompensated cirrhosis at risk of infection? J Hepatol 2012, in press. IF 9.334

Requardt RP, Hirrlinger PG, Wilhelm F, Winkler U, Besser S, Hirrlinger J: Ca2+ signals of astrocytes are modulated by the NAD+/NADH redox state. J Neurochem 2012, 120:1014-1025. IF 4.337

Richter F, Bauer R, Ebersberger A, Lehmenkuhler A, Schaible HG: Enhanced neuronal excitability in adult rat brainstem causes widespread repetitive brainstem depolarizations with cardiovascular consequences. J Cereb Blood Flow Metab 2012 Mar 28 [Epub ahead of print]. IF 4.522

Ringer TM, Axer H, Romeike BFM, Zinke J, Brunkhorst FM, Witte OW, Günther A: Neurological sequelae of sepsis: I) Septic encephalopathy. The Open Critical Care Medicine Journal 2011, 4: 2-7.

Rosendahl J, Brunkhorst FM, Jaenichen D, Strauss B: Physical and mental health in patients and spouses following intensive care of severe sepsis: a dyadic perspective on long-term sequelae testing the Actor-Partner Interdependence Model. Crit Care Med 2012, in press  IF 6.254 

Schmerler D, Neugebauer S, Ludewig K, Bremer-Streck S, Brunkhorst FM, Kiehntopf M: Targeted Metabolomics for discrimination of systemic inflammatory disorders in critically ill patients. J Lipid Res 2012, 53:1369-1375. IF 6.115

Schmidt K, Thiel P, Mehlhorn J, Mueller F, Gensichen J:  Aspects of sepsis care in general practice. Intensiv- und Notfallbehandlung. in press 

Schubert H, Eiselt M, Walter B, Fritz H, Brodhun M, Bauer R: Isoflurane/nitrous oxide anesthesia and stress-induced procedures enhance neuroapoptosis in intrauterine growth-restricted piglets. Intensive Care Med 2012, 38:1205-1214. IF 4.996

Seider K, Brunke S, Schild L, Jablonowski N, Wilson D, Majer O, Barz D, Haas A, Kuchler K, Schaller M, Hube B: The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation. J Immunol 2011, 187(6):3072-86. IF 5.745

Sobke A, Klinger M, Hermann B, Sachse S, Nietzsche S, Makarewicz O, Keller PM, Pfister W, Straube E. The urinary antibiotic 5-nitro-8-hydroxyquinoline (nitroxoline) reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Antimicrob Agents Chemother. 2012 Aug 27. [Epub ahead of print]. IF 4.841

Sponholz C, Huse K, Kramer M, Giamarellos-Bourboulis EJ, Claus RA, Engel C, Kuhnt E, Kiehntopf M, Brunkhorst FM, Routsi C, Mylona V, Tsangaris I, Heinemann SH, Reinhart K, Platzer M, Bauer M: Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis. Shock in press IF 3.203

Tierney L, Linde J, Müller S, Brunke S, Molina JC, Hube B, Schöck U, Guthke R, Kuchler K: An Interspecies Regulatory Network Inferred from Simultaneous RNA-seq of Candida albicans Invading Innate Immune Cells. Front Microbiol 2012, 3:85. IF 7.600

Thomas-Rueddel DO, Vlasakov V, Reinhart K, Jaeschke R, Rueddel H, Hutagalung R, Stacke A, Hartog CS: Safety of gelatin for volume resuscitation - a systematic review and metaanalysis. Intensive Care Med 2012, 38:1134-42. IF 4.996

Tzepi IM, Giamarellos-Bourboulis EJ, Carrer DP, Tsaganos T, Claus RA, Vaki I, Pelekanou A, Kotsaki A, Tziortzioti V, Topouzis S, Bauer M, Papapetropoulos A: Angiopoietin-2 enhances survival in experimental sepsis induced by multidrug-resistant Pseudomonas Aeruginosa. J Pharmacol Exp Ther 2012, E-pub Aug2. IF 4.017

Wächtler B, Citiulo F, Jablonowski N, Förster S, Dalle F, Schaller M, Wilson D, Hube B: Candida albicans-Epithelial Interactions: Dissecting the Roles of Active Penetration, Induced Endocytosis and Host Factors on the Infection Process. PLoS One 2012, 7(5):e36952. IF 4.411

Weber M, Lambeck S, Ding N, Henken S, Kohl M, Deigner HP, Enot DP, Igwe EI, Frappart L, Kiehntopf M, Claus RA, Kamradt T, Weih D, Vodovotz Y, Briles DE, Ogunniyi AD, Paton JC, Maus UA, Bauer M: Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. FASEB J 2012 Jun, 26(6):2424-36. IF 6.515

Vassilev T, Bauer M: Passive immunotherapy of sepsis with intravenous immune globulin: not all IVIg preparations are created equal. Crit Care. 2012 Jan 25, 16(1):407. IF 4.595

Bücher und Buchkapitel

Axer H, Rosengarten B:  CIP, CIM, septische Enzephalopathie. In: Sepsis und MODS. 5. Auflage. Springer-Verlag, 2012 in press.

Bloos F, Bauer M, Reinhart K: Pathophysiologie der Sepsis und des Multiorganversagens. In: AINS Band 2: Intensivmedizin. Thieme-Verlag, 2012 in press

Brunkhorst FM, Welte T: Sepsis und schwere Sepsis - aktuelle Aspekte zur leitliniengerechten Diagnostik und Therapie. in: GERMAP 2010 - Bericht über den Antibiotikaverbrauch und die Verbreitung von Antibiotikaresistenzen in der Human- und Veterinärmedizin in Deutschland. November 2011. ISBN 978-3-00- 0316227

Hagel S, Pletz MW: Skin infections, Osteomyelitis. Rationale Diagnostik und Therapie in der Inneren Medizin. Eds: Meyer J, Dierkesmann R, Elsevier (2011).

Hagel S, Stallmach A: Gastrointestinal Infections. Intensivmedizin. Eds: Van Aken H, Reinhart K, Zimpfer M, Welte T. Stuttgart, Georg Thieme Verlag, 2011.

Lüttich A, Brunke S, Hube B: Isolation and amplification of fungal RNA for microarray analysis from host samples. Methods Mol Biol 2012, 845:411-21.

Reinhart K, Brunkhorst FM: Prevention, Diagnosis, Therapy and Follow-up Care of Sepsis. Stuttgart, Georg Thieme Verlag, 2011.

Reinhart K, Bloos F: Pathophysiology of Sepsis and Multiple Organ Dysfunction. In: Vincent JL, Abraham E, Moore FA, Kochanek PM, Fink MP (eds). Textbook of Critical Care. 6th edition. Elsevier Saunders, Philadelphia 2011: 983-991.

Stäubert S, Löbe M, Meineke F: Forschungsschwerpunkte im IFB. Data Center in 10 th Leipzig Research Festival for Life Sciences 2011, Hrsg: J. Thiery, A. Beck-Sickinger, T. Arendt , ISBN 978-3-9810760-7-3

Publikationen mit Bezug zum Konzept des CSCC sowie strukturellen Defiziten in der akademischen Medizinausbildung Deutschlands

Stallmach A, Bauer M, Witte OW, Siegmund B: Strategien zur Sicherung des wissenschaftlichen Nachwuchses. Dtsch Arztebl 2011, 108(8): A 380-2

Stallmach A, Hagel S, Bruns T, Bauer M: [Cut a long story too short: Challenges in clinical research]. Dtsch Med Wochenschr 2012 Mar, 137(10):496-500. IF 0.500

*Authoren mit CSCC-Affiliation sind hervorgehoben