Thematic direction and prerequisites for research

The focus of the CSCC is directed to sepsis including its long-term sequelae.
The center will adequately meet the following conditions and requirements:

1. the important clinical value of sepsis, which increasingly turns out to be a limitating parameter for the success of surgical und other medical fields
2. the necessity of eliminating deficits in research and clinical care of the patients
3. the use of the expertise of Jena scientists in the field of neurodegeneration and functional recovery for the analysis of sepsis sequalae.

Steps forward in the development of therapeutic innovative basic approaches and the reduction of high mortality can only be realised, if it will be possible:

• to have a better understanding of the predisposition for the development of sepsis in order to identify the infectious agents and their pathogenicity factors in a better and faster manner
• to characterise the "response", i.e. the cell biological host-pathogen interactions, using appropriate sepsis markers, which can better map the biochemical changes than previous clinical and laboratory diagnostic criteria
• to early diagnose the organ dysfunction of sepsis, including the acute septic encephalopathy, and to better understand the sepsis sequelae.

Research areas

A Risk Assessment and Sepsis Control

B Novel Diagnostic Tools and Approaches

C Acute Care

D Sepsis related Organ Failure

E Long-term Sequelae

F Public Health

Projects Research Area A - Risk Assessment and Sepsis Control

Alerts
Effectiveness of a Hospital-wide Educational Programme for Infection Control to Reduce the Rate of Health-Care Associated Infections and related Sepsis

Peiras
Response to Homeostatic Disturbance for Individualized Risk Assessment in Sepsis

CNV
Impact of copy number variations within the defensin locus on 8p23 and the cystathionine beta synthase gene in human sepsis and sepsis complications

SepsEXOME
High-throughput DNA sequencing to identify rare host variants in bacterial sepsis

TRAFFIC
The role of TRAF6 in modulating monocytic immune responses and mediating infections in cirrhosis

SepsiMet
Sepsis and metabolic alterations

Osarst
Obstructive Sleep Apnea postoperative Risk Stratification Trial

Pred-Sep
Predictors of Sepsis - Assessment of brain induced immunodepression by markers of autonomic control

Anti-biofilm
Screening for bio-active and anti-biofilm substances of Bacillus and Paenibacillus species

NuRe-demirCa
Nuclear Receptor-dependent modulation of the immune response induced by Candida albicans: Impact of Pattern Recognition Receptor transrepression

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Projects Research Area B - Novel Diagnostic Tools and Approaches

Lab-Alerts
Laboratory nested co-study of the: ”Effectiveness of a Hospital-wide Educational Programme for Infection Control to Reduce the Rate of Health-Care Associated Sepsis"

Drift
Characterization of a phenotypic drift in chronic infection

Action
Prognostic and Diagnostic Relevance of Bacterial DNA Detection in Patients with Liver Cirrhosis and Ascites at Risk for Spontaneous Bacterial Peritonitis - a prospective multicenter study

Spade
Novel Diagnostic Tools for Culture-Independent Sepsis Pathogen Detection

Shilers
Spectral Hemogram for the Investigation of LEukocytes and their Role in Septicemia

Premospec
Prediction models for antibiotic susceptibility based on Raman spectroscopy

Aras
Androgen-Regulation of the Sepsis response: Beneficial role of androgen receptor antagonists?

TransSeptomics
Integrative analysis of omics data from experimental and clinical sepsis in a translational approach towards individualized prevention, diagnosis and therapy.

CanSep
Identification of protein antigens from Candida albicans for fungal sepsis diagnostics

Inprot
Identification of Candida albicans and Aspergillus fumigatus protein antigens for fungal diagnostics and investigation of the A. fumigatus stress response

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Projects Research Area C - Acute Care
                                         

Medusa
Medical Education for Sepsis Source Control and Antibiotics

PCT
Meta-analysis of procalcitonin (PCT) as diagnostic test and guided therapy for sepsis

Eidecs
End-of-life Decision-Making in Patients with Sepsis related Organ Failure

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Projects Research Area D - Sepsis related Organ Failure                                                                               

Praise
A prospective, multi-center, randomized, double-blinded, placebo-controlled study for the evaluation of lloprost in the early postoperative period after liver transplantation

HHDP
Heme, Heme Degradation Products and Systems Biology of Sepsis-associated Organ Failure

HIFMORG
Role of HIF-1α and MORG1 in sepsis induced renal injury

SMAD2
Analysis of the mechanisms of chronification in a sepsis model in a cell- or organ-specific smad2 K.O. mouse

Candida
Pathogen-Host Interaction during Infection with Candida albicans and its Progression to Sepsis

SomatostatinR
The somatostatin receptor 2A as a possible therapeutic target in sepsis and associated liver-dysfunction

PI3Kgamma
Dual role of PI3Kγ in the pathogenesis of septic cardiomyopathy

Rosisep
Role of reactive oxygen species (ROS) in septic myocardial dysfunction

ADAMTS13
Sepsis-associated Microthrombus Formation: Processing and Secretion of von-Willebrand Factor Cleaving Protease

Thrombomodulin
Role of the Lectin-like Domain of Thrombomodulin in Murine Sepsis-Induced Cardiac Depression

Liver Dysfunction
Sepsis-induced liver failure: Molecular mechanisms and functional significance of excretory dysfunction and impact on critical care pharmacology

Seda
Regulation of sepsis-induced endothelial cell dysfunction by 5’ AMP-activated protein kinase (AMPK)

Sephi
Protein acetylation in sepsis - modulation by inhibitors of protein deacetylases (HDACi)

Mime
Role of Nhe1 and Nkcc1 in the pathophysiology of sepsis

MomCanSep
Molecular Mechanisms of Candida Sepsis

Duo-LBP
G-CSF revisited - Dual role of LBP in SIRS and sepsis Opposing function of LBP

Miras
AMPK associated insulin resistance in inflammation and sepsis

SphingoHSC
Role of low-molecular-weight inhibitors of acid sphingomyelinase in sepsis-induced hepatic stellate cell activation

Pneumo-HSC
Hepatic stellate cell activation during pneumonia

S1P
Diagnostic risk assessment and therapeutic modulation of local and systemic sphingosine 1-phosphate (S1P) concen­trations and S1P-receptors for sepsis control

ResolveAKI
Mechanisms promoting and resolving - acute kidney injury in sepsis

Sensepsys
Establishing a molecular sensor for detection and treatment of sepsis

Leptin
Recovery of energy metabolism in sepsis via leptin up-regulation by glucocorticoids as a new mechanism protecting from organ failure

CEA family receptors: a novel class of immuno-regulatory proteins interacting with Candida albicans

Phosphatidycholine
Modification of gut barrier dysfunction in sepsis by phosphytidylcholine

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Projects Research Area E - Long-term Sequelae

Anergy
T-cell paralysis in sepsis

TPHS
Satellite Project of ANERGY: T-cell paralysis in human Sepsis

Loss
Long-term Immunological Sequelae in Sepsis-Survivors

MDSC-iRESP
Evaluation of Functional Interaction between Myeloid-derived Suppressor Cells and Immune Response of Sepsis Patients

Regeffect
Phenotypical and Functional Delineation of Regulatory T Cell Subpopulations and their Effect on Lymphocyte Activation and Effector Function in Sepsis 

Recuperate
Reconstitution of immunity in sepsis survivors

NeuroSOS-Nerve/CIP
Neurological Sequelae of Sepsis

NeuroSOS-Dysphagia
Neurological Sequelae of Sepsis (NeuroSOS-DYSPHAGIA): Chronic dysphagia in patients with critical illness polyneuropathy (CIP) or myopathy (CIM)

SepMech
Long-term impact of Sepsis-associated Encephalopathy: Mechanisms and therapeutic options

NeuroSOS-Enc
Synaptic transmission dysfunction in experimental septic encephalopathy

NeuroPain
Neurological sequelae and changes in nociception after severe sepsis or septic shock

Smooth
Sepsis survivors monitoring and coordination in outpatient health care

Loss-Cog-Train
Long-term Cognitive and Functional Outcome of Survivors of Severe Sepsis following a computerized Cognitive Training

Crisis
Stress disorders following critical illness in patients with severe sepsis

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Projects Research Area F - Public Health

Cost-Alerts
Cost-effectiveness analysis of the Alerts study

Epidemiology and global burden of sepsis - A systematic review of observational epidemiological studies

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